Diagnostic Clinical Genome and Exome Sequencing

n engl j med 371;12 nejm.org september 18, 2014 1169 not. This suggests that differences with previous studies may be explained by residual confounding in those studies. Our study addresses only one piece of the complex risk–benefit equation of antidepressant use in pregnancy, during which other risks associated with antidepressant use have been well documented. Our findings certainly do not justify incautious use of such drugs in these patients. Krista F. Huybrechts, Ph.D.