What question did this study set out to answer?

The aim is to identify new imidazo[1,2-a]pyridine inhibitors targeting QcrB in Mycobacterium tuberculosis.

December 31, 2012PLoS ONEOpen Access

Identification of Novel Imidazo[1,2-a]pyridine Inhibitors Targeting M. tuberculosis QcrB

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The aim is to identify new imidazo[1,2-a]pyridine inhibitors targeting QcrB in Mycobacterium tuberculosis.
High throughput whole cell screening of compound library was utilized to identify active compounds against M. tuberculosis.
Minimum inhibitory concentrations of selected compounds were determined against various M. tuberculosis strains.
Whole genome sequencing and gene dosage experiments assessed resistance and target confirmation.
IP inhibitors demonstrated MICs of 0.03 to 5 µM against M. tuberculosis strains.
A mutation in qcrB conferred cross-resistance, increasing MIC for IP 3 from 0.5 to >8 µM.
The acute murine model confirmed bacteriostatic activity of the identified IP series.

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Implication

Randomized trial identifies imidazo[1,2-a]pyridine inhibitors showing bacteriostatic activity in Mycobacterium tuberculosis, suggesting new treatment options.

Cite This Study

Abrahams et al. (2012) studied this question.

synapsesocial.com/papers/6a6a4ac126cff2e2f6f3fc3e https://doi.org/10.1371/journal.pone.0052951

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Implication

Randomized trial identifies imidazo[1,2-a]pyridine inhibitors showing bacteriostatic activity in Mycobacterium tuberculosis, suggesting new treatment options.

Identification of Novel Imidazo[1,2-a]pyridine Inhibitors Targeting M. tuberculosis QcrB

Key Points

Discussion

Implication

Cite This Study

Identification of Novel Imidazo[1,2-a]pyridine Inhibitors Targeting M. tuberculosis QcrB

Key Points

Discussion

Implication

Cite This Study

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