What question did this study set out to answer?

This research aims to characterize the role of NADH:menaquinone oxidoreductase in the respiratory chain of Mycobacterium tuberculosis and to evaluate phenothiazine analogs as potential antitubercular agents.

March 14, 2005Proceedings of the National Academy of SciencesOpen Access

Inhibitors of type II NADH:menaquinone oxidoreductase represent a class of antitubercular drugs

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Authors

EWEdward A. WeinsteinPfizer (United States)TYTakahiro YanoUniversity of Tsukuba LLLinsheng LiHebei North University

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Implication

Randomized trial demonstrates significant tuberculocidal activity of phenothiazine analogs in Mycobacterium tuberculosis, highlighting potential for new antibiotics.

Key Points

This research aims to characterize the role of NADH:menaquinone oxidoreductase in the respiratory chain of Mycobacterium tuberculosis and to evaluate phenothiazine analogs as potential antitubercular agents.
Detailed biochemical characterization of aerobic respiratory chains in Mycobacterium tuberculosis.
In vitro testing of phenothiazine analogs for NADH:menaquinone oxidoreductase inhibition.
Evaluation of phenothiazine effectiveness in a mouse model of acute infection.
Phenothiazine analogs significantly inhibit NADH:menaquinone oxidoreductase activity.
Several analogs show high tuberculocidal efficacy in vitro.
Phenothiazine analogs effectively suppress Mycobacterium tuberculosis growth in a mouse model.

Cite This Study

Weinstein et al. (2005) studied this question.

synapsesocial.com/papers/6a6a4ac126cff2e2f6f3fc47 https://doi.org/10.1073/pnas.0500469102

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Implication

Randomized trial demonstrates significant tuberculocidal activity of phenothiazine analogs in Mycobacterium tuberculosis, highlighting potential for new antibiotics.

Inhibitors of type II NADH:menaquinone oxidoreductase represent a class of antitubercular drugs

Discussion

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Implication

Key Points

Cite This Study

Inhibitors of type II NADH:menaquinone oxidoreductase represent a class of antitubercular drugs

Discussion

Member takes

Implication

Key Points

Cite This Study

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