Key result
Sulfated polysaccharides from Grateloupia filicina demonstrate anticoagulant activity in vitro.
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Sulfated polysaccharides (GSP) were isolated from the cloned Grateloupia filicina which was cultured in Jiaozhou Bay, Qingdao, China. The yield of GSP was 15.75%. The total sugar and sulfate were 40.90 and 19.89%, respectively. And the average molecular weight was 11.7 KDa. The results of neutral sugar analysis showed that GSP was mainly sulfated polysaccharides of galactose. The experiments for activated partial thromboplastin time (APTT), prothrombin time (PT), and thrombin time (TT) anticoagulant assays in vitro indicated that GSP was a good potential anticoagulant. Therefore, this study supplied new thought for the cloned Grateloupia filicina exploitation of high-value products.
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Chen et al. (2015) studied this question. Sulfated polysaccharides (GSP) was evaluated on Anticoagulant activity (APTT, PT, TT in vitro). Sulfated polysaccharides (GSP) isolated from Grateloupia filicina demonstrated potential anticoagulant activity in vitro.
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