Key result
A 15-week hypocaloric diet and exercise intervention in severely obese subjects reduced body weight (P<0.001) and improved inflammatory markers in plasma and adipose tissue, but not skeletal muscle.
Why the study?
Does a 15-week hypocaloric diet and daily exercise intervention reduce inflammatory markers in severely obese subjects?
Population
27 severely obese subjects, mean body mass index 45.8 kg/m2
Design
Cohort
Follow-up
15 weeks
Authors
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Lifestyle changes may lower adipose inflammation in severe obesity; leaves open differential tissue responses and need for controlled trials.
Does a 15-week hypocaloric diet and daily exercise intervention reduce inflammatory markers in severely obese subjects?
A 15-week hypocaloric diet and exercise intervention in severely obese subjects improves insulin sensitivity and reduces systemic and adipose tissue inflammation, but not skeletal muscle inflammation.
Bruun et al. (2005) studied Severe obesity (n=27). Hypocaloric diet and daily exercise was evaluated on Inflammatory markers in plasma, adipose tissue, and skeletal muscle. A 15-week hypocaloric diet and exercise intervention in severely obese subjects reduced body weight (P<0.001) and improved inflammatory markers in plasma and adipose tissue, but not skeletal muscle.
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