Key result
Hypertrophy induced by partial vein ligation in rabbits resulted in an approximately threefold increase in intermediate filaments per cross-sectional area compared to controls at 14 days.
Population
Rabbit vascular smooth muscle (portal-anterior mesenteric vein)
Comparison
Hypertrophy induced by partial ligation of the… vs Control (non-hypertrophied) vascular smooth muscle
Design
Preclinical
Follow-up
14 days
Authors
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Does not inform clinical vascular management; leaves open whether intermediate filament upregulation drives human smooth muscle hypertrophy.
Effect estimate: approximately threefold increase
Hypertrophy in vascular smooth muscle is associated with a disproportionate increase in intermediate filaments and actin filaments relative to myosin.
Berner et al. (1981) studied Vascular smooth muscle hypertrophy. Partial ligation of the portal-anterior mesenteric vein vs. Control was evaluated on Number of intermediate filaments per cross-sectional area (approximately threefold increase). Hypertrophy induced by partial vein ligation in rabbits resulted in an approximately threefold increase in intermediate filaments per cross-sectional area compared to controls at 14 days.
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