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September 18, 2008Blood Vessels

Contractile System Function in Mammalian Smooth Muscle

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Key result

Mammalian smooth muscle exhibits considerable uniformity in contractile function, often developing equal or greater maximum isometric force per cross-sectional area compared to striated muscle.

Population

Mammalian smooth muscle preparations

Design

Review

Authors

RMRichard A. MurphyUniversity of Southern California

Discussion

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Implication

Does not support changes in vascular management; leaves open translation to human disease models.

Structured PICO

P
Population
Mammalian smooth muscle preparations
C
Comparator
Vertebrate striated muscles
O
Outcome
Contractile system function (maximum isometric force, shortening velocities, operating lengths)

Mammalian smooth muscle exhibits considerable uniformity in contractile function, with equal or greater maximum isometric force but lower shortening velocities compared to striated muscle, likely utilizing a similar sliding filament mechanism.

Limitations

  • Few details are known of filament structure, organization, interactions, and force transmission compared to striated muscle.
  • Tissue or cellular mechanical parameters may not be directly proportional to the output of the myofilamental contractile unit.
  • Few details are known of filament structure, organization, interactions, and of force transmission in comparison with striated muscle

Cite This Study

Richard A. Murphy (2008) conducted a review in Mammalian smooth muscle function. Mammalian smooth muscle exhibits considerable uniformity in contractile function, often developing equal or greater maximum isometric force per cross-sectional area compared to striated muscle.

synapsesocial.com/papers/6a843ffb4d02f4f0268d76a6https://doi.org/10.1159/000158076
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Filament Organization and Contractile Function in Vertebrate Smooth Muscle1979 · 54 citations
  2. 2Variations of the Contractile Apparatus in Smooth and Striated Muscles1967 · 47 citations
  3. 3Structure‐function relationships in smooth muscle: The missing links1995 · 100 citations
  4. 4`Sarcomeres' of smooth muscle: functional characteristics and ultrastructural evidence2005 · 124 citations
  5. 5The biophysics and biochemistry of smooth muscle contraction1992 · 28 citations