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This research aims to analyze the structural differences in cerebral vessels of spontaneously hypertensive rats compared to normotensive ones.

May 1, 1980StrokeOpen Access

Morphometric study on cerebral vessels in spontaneously hypertensive rats.

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Morphometric study determines vessel structure differences in hypertensive rats, indicating vascular changes early in life.

This research aims to analyze the structural differences in cerebral vessels of spontaneously hypertensive rats compared to normotensive ones.
Utilized a modified morphometrical method based on Furuyama's technique.
Analyzed cerebral arterial vessels in both spontaneously hypertensive and normotensive rats at 15 and 200 days old.
Measured media thickness and lumen radius to determine the media/radius ratio.
Significant increase in media/radius ratio observed in medium and large vessels of 15-day-old SHR.
Increased media cross-section area and lumen radius noted in internal carotid arteries of young SHR.
At 200 days, smaller arterioles in SHR showed a significantly increased media/radius ratio compared to local Wistar rats.

Nordborg et al. (1980) studied this question.

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