Peri-Atrial Epicardial Adipose Tissue Is Associated With New-Onset Nonvalvular Atrial Fibrillation
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Key result
Peri-atrial epicardial adipose tissue volume was an independent predictor of new-onset atrial fibrillation (OR 1.28 per 1 ml/m2 increase) in patients with coronary artery disease.
Why the study?
Does peri-atrial epicardial adipose tissue volume predict new-onset nonvalvular atrial fibrillation in patients evaluated for coronary artery disease?
Population
279 patients with no history of atrial fibrillation who underwent MDCT examination for evaluation of…
Design
Cohort
Follow-up
3.3±1.0 years
Authors
Discussion
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Implication
May refine AF risk stratification via MDCT in CAD; leaves open causal role and therapeutic targeting.
Study Design
Type
Cohort (n=279)
Blinding
Single-blind
Multicenter
No
Structured PICO
Does peri-atrial epicardial adipose tissue volume predict new-onset nonvalvular atrial fibrillation in patients evaluated for coronary artery disease?
P
Population
279 patients (mean age 65, 37% female) undergoing MDCT for coronary artery disease evaluation without prior atrial fibrillation, followed for a mean of 3.3 years.
E
Exposure
Peri-atrial epicardial adipose tissue (EAT) volume assessment by multidetector computed tomography (MDCT)
O
Outcome
New-onset nonvalvular atrial fibrillationhard clinical
Main Result
Odds Ratio: 1.28 (95% CI 1.13–1.45)
p-value: p=<0.001
Peri-atrial epicardial adipose tissue volume assessed by MDCT is a strong, independent predictor of new-onset nonvalvular atrial fibrillation in patients with coronary artery disease.
Limitations
- Subanalysis of a single-center prospective database
- Waist circumference was not assessed
- Incidence of asymptomatic AF might be underestimated due to intermittent ECG monitoring
- EAT volumes were indexed for body surface area, which requires further validation
- Small number of patients may have obscured the contribution of hypertension and CAD
- Histopathologic analysis of EAT was not performed
Cite This Study
Nakanishi et al. (2012) conducted a cohort in Coronary artery disease (n=279). Peri-atrial epicardial adipose tissue (EAT) volume vs. Lower peri-atrial EAT volume was evaluated on New-onset nonvalvular atrial fibrillation (OR 1.28, 95% CI 1.13-1.45, p=<0.001). Peri-atrial epicardial adipose tissue volume was an independent predictor of new-onset atrial fibrillation (OR 1.28 per 1 ml/m2 increase) in patients with coronary artery disease.
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