Key result
Lower serum matrix metalloproteinase-9 levels were significantly associated with preeclampsia and demonstrated excellent predictive ability for the condition in preterm pregnancies (AUC 0.980).
Why the study?
To investigate whether metalloproteinases could be used as predictors of preeclampsia during pregnancy.
Does matrix metalloproteinase-9 (MMP-9) level predict preeclampsia in pregnant women?
Case-Control (n=100)
No
Does matrix metalloproteinase-9 (MMP-9) level predict preeclampsia in pregnant women?
Mean Difference: 9.2
Absolute Event Rate: 22.5% vs 31.7%
p-value: p=0.001
MMP-9 levels are significantly lower in women with preeclampsia and may serve as a strong predictor of the condition, particularly in preterm pregnancies.
Caution against clinical use of MMP-9 testing; hypothesis-generating for preterm preeclampsia and requires prospective validation.
Objectives: The goal of this research was to investigate whether metalloproteinases could be used as predictors of preeclampsia (PE) during pregnancy. Materials and Methods: This case-control study included 100 pregnant women which they further grouped into PE and control group (each composed of 50 women). Both groups were further subdivided according to their gestational age (GA), using the 37th week of gestation as a divider, as preterm and term infants. Results: In both preterm (P=0.001) and term infants (P=0.001), mean metalloproteinase-9 (MMP-9) was considerably lower in PE mothers compared to controls, with the difference being greater in preterm infants. In ROC analysis, MMP-9 showed excellent ability to predict PE in preterm infants (AUC = 0.980, cut-off ≤26.2) and good ability to predict PE in term infants (AUC 0.770, cut-off ≤ 34.4). Conclusions: The matrix MMP-9 is a non-specific predictor of PE for term and preterm pregnant women, with higher accuracy for preterm pregnant women.
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Mourad et al. (2023) conducted a case-control in Preeclampsia (n=100). Serum Matrix Metalloproteinase-9 (MMP-9) levels vs. Healthy pregnant women was evaluated on Mean MMP-9 levels in preterm pregnancies (MD 9.2, p=0.001). Lower serum matrix metalloproteinase-9 levels were significantly associated with preeclampsia and demonstrated excellent predictive ability for the condition in preterm pregnancies (AUC 0.980).
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