Key result
Antiarrhythmic drugs can be classified based on their effectiveness in six in vivo animal arrhythmia models, which may be useful for predicting clinical efficacy and proarrhythmic potential.
Why the study?
How do different classes of antiarrhythmic drugs affect various in vivo arrhythmia models?
Population
6 in vivo arrhythmia models, mainly using dogs
Design
Preclinical
Authors
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Supports preclinical antiarrhythmic classification in canine models; leaves open clinical translation.
How do different classes of antiarrhythmic drugs affect various in vivo arrhythmia models?
Different classes of antiarrhythmic drugs exhibit distinct profiles of efficacy and proarrhythmia across various in vivo dog models, which may aid preclinical drug development.
Keitaro Hashimoto (2007) conducted a review in Arrhythmia. Antiarrhythmic drugs was evaluated on Effectiveness on 6 in vivo arrhythmia models. Antiarrhythmic drugs can be classified based on their effectiveness in six in vivo animal arrhythmia models, which may be useful for predicting clinical efficacy and proarrhythmic potential.
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