Key result
Eliprodil moderately lengthens cardiac repolarization by inhibiting I(Kr) under normal conditions, but induces marked QTc prolongation and proarrhythmic action when repolarization reserve is attenuated.
Why the study?
Does eliprodil prolong cardiac repolarization and increase proarrhythmic risk in models with attenuated repolarization reserve?
Population
Canine right ventricular papillary muscle, Langendorff-perfused rabbit heart, and dog ventricular myocytes
Comparison
Eliprodil administered under normal conditions… vs Baseline conditions and BaCl2 alone
Design
Preclinical
Authors
Loading...
May impair repolarization when reserve is reduced; leaves open clinical proarrhythmic relevance.
Does eliprodil prolong cardiac repolarization and increase proarrhythmic risk in models with attenuated repolarization reserve?
Eliprodil inhibits IKr and moderately prolongs repolarization, but poses a significant proarrhythmic risk when the repolarization reserve is reduced.
Lengyel et al. (2004) studied Cardiac repolarization (in vitro/animal model). Eliprodil vs. Normal conditions vs BaCl2 (attenuated repolarization reserve) was evaluated on Action potential duration (APD) and QTc prolongation. Eliprodil moderately lengthens cardiac repolarization by inhibiting I(Kr) under normal conditions, but induces marked QTc prolongation and proarrhythmic action when repolarization reserve is attenuated.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: