Key result
Magnesium infusion significantly decreased the amplitude of cesium-induced early afterdepolarizations (from 49.7% to 31.2%, p<0.003) and reduced ventricular tachyarrhythmias in dogs.
Why the study?
Does magnesium infusion suppress early afterdepolarizations and ventricular tachyarrhythmias induced by cesium in dogs?
Population
Dogs (n=13) with cesium-induced early afterdepolarizations and ventricular tachyarrhythmias
Comparison
Magnesium infusion vs Baseline and 1 to 2 hours after discontinuation…
Design
Preclinical
Follow-up
1 to 2 hours after discontinuation of infusion
Authors
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Magnesium suppresses EADs and triggered activity in Purkinje fibers; leaves open mechanistic and clinical translation to torsades.
Does magnesium infusion suppress early afterdepolarizations and ventricular tachyarrhythmias induced by cesium in dogs?
Absolute Event Rate: 31.2% vs 49.7%
p-value: p=<0.003
Magnesium infusion suppresses cesium-induced early afterdepolarizations and ventricular tachyarrhythmias in a canine model, providing a mechanistic basis for its use in long QT syndrome and torsades de pointes.
Bailie et al. (1988) studied Cesium-induced early afterdepolarizations and ventricular tachyarrhythmias (n=13). Magnesium infusion vs. Before magnesium infusion (baseline) was evaluated on Amplitude of early afterdepolarizations as a percentage of monophasic action potential amplitude (p=<0.003). Magnesium infusion significantly decreased the amplitude of cesium-induced early afterdepolarizations (from 49.7% to 31.2%, p<0.003) and reduced ventricular tachyarrhythmias in dogs.
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