Key result
Beta-blockade prevented sustained ventricular tachycardia in dogs with cesium chloride-induced long QT syndrome, whereas left stellate stimulation accelerated its onset (0.58 vs 1.21 mmol/kg; p<0.001).
Why the study?
Does autonomic intervention modulate arrhythmogenesis and MAP characteristics in a canine model of cesium chloride-induced long QT syndrome?
Population
24 dogs with atrioventricular node ablation followed by ventricular pacing, given increasing doses of cesium…
Comparison
Autonomic interventions: total denervation… vs Control group (no autonomic intervention)
Design
Preclinical
Authors
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Autonomic modulation of cesium-induced triggered activity in dogs leaves open relevance to human ventricular arrhythmias.
Does autonomic intervention modulate arrhythmogenesis and MAP characteristics in a canine model of cesium chloride-induced long QT syndrome?
Absolute Event Rate: 0.58% vs 1.21%
p-value: p=<0.001
Autonomic tone modulates the expression of early afterdepolarizations as sustained ventricular tachycardia in a canine model of long QT syndrome, with beta-blockade preventing sustained arrhythmia.
Hanich et al. (1988) studied cesium chloride-induced long QT syndrome (n=24). Autonomic interventions (total denervation, beta-blockade, left stellate stimulation) vs. control was evaluated on Dose of CsCl required to induce sustained ventricular tachycardia (p=<0.001). Beta-blockade prevented sustained ventricular tachycardia in dogs with cesium chloride-induced long QT syndrome, whereas left stellate stimulation accelerated its onset (0.58 vs 1.21 mmol/kg; p<0.001).
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