Key result
Abdominal obesity class II in acute ischemic stroke was associated with reduced adiponectin and transiently elevated leptin and HOMA-IR, which directly correlated with cerebral infarction volumes.
Why the study?
Does abdominal obesity alter adipokine levels and insulin resistance in patients with acute ischemic non-lacunar hemispheric stroke?
Observational
Does abdominal obesity alter adipokine levels and insulin resistance in patients with acute ischemic non-lacunar hemispheric stroke?
Abdominal obesity in acute ischemic stroke is associated with adverse neuroendocrine changes that correlate with larger cerebral infarction volumes, potentially explaining more severe strokes in this population.
Neuroendocrine profiling may refine prognosis in obese acute stroke; leaves open causal validation and intervention trials.
It has been examined serum concentrations of adiponectin, leptin and insulin resistance HOMA-IR index among patients with abdominal obesity II class and normal body weight patients in the acute phase of ischemic non-lacunar (atherothrombotic and cardioembolic) hemispheric strokes. There was absence of any significant difference in adipokines concentration and insulin resistance in normal body weight patients with acute stroke. Under the conditions of acute ischemic non-lacunar hemispheric stroke, patients with abdominal obesity II class have sustained reduction of adiponectin serum level at 1st and 10th day after stroke and transient elevation of leptin serum level, as well as HOMA-IR index at 1st day with subsequent return to basal values on the 10th day. The extents of these neuroendocrine changes in abdominally obese patients have a direct association with cerebral infarction volumes. These neuroendocrine peculiarities may be, at least partly, one reason of more severe stroke in abdominally obese patients.
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Delva et al. (2019) conducted an observational in Acute ischemic non-lacunar hemispheric stroke. Abdominal obesity II class vs. Normal body weight was evaluated on Serum concentrations of adiponectin, leptin and HOMA-IR index. Abdominal obesity class II in acute ischemic stroke was associated with reduced adiponectin and transiently elevated leptin and HOMA-IR, which directly correlated with cerebral infarction volumes.
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