Key result
Severe abdominal obesity in ischemic stroke is linked to adipokine dysregulation and larger infarct volumes.
Why the study?
Does abdominal obesity alter adipokine levels and insulin resistance in patients with acute ischemic non-lacunar hemispheric stroke?
Observational (n=45)
No
Does abdominal obesity alter adipokine levels and insulin resistance in patients with acute ischemic non-lacunar hemispheric stroke?
p-value: p=<0.05
Abdominal obesity is associated with a distinct neuroendocrine stress response (lower adiponectin, higher leptin, and insulin resistance) during acute ischemic stroke that may contribute to greater cerebral infarction volumes and more severe disease.
Abdominal obesity links to distinct adipokine and insulin resistance profiles in acute non-lacunar stroke; hypothesis-generating for infarct volume mediation and requires prospective validation.
It has been examined serum concentrations of adiponectin, leptin and insulin resistance HOMA-IR index among patients with abdominal obesity II class and normal body weight patients in the acute phase of ischemic non-lacunar (atherothrombotic and cardioembolic) hemispheric strokes. There was absence of any significant difference in adipokines concentration and insulin resistance in normal body weight patients with acute stroke. Under the conditions of acute ischemic non-lacunar hemispheric stroke, patients with abdominal obesity II class have sustained reduction of adiponectin serum level at 1st and 10th day after stroke and transient elevation of leptin serum level, as well as HOMA-IR index at 1st day with subsequent return to basal values on the 10th day. The extents of these neuroendocrine changes in abdominally obese patients have a direct association with cerebral infarction volumes. These neuroendocrine peculiarities may be, at least partly, one reason of more severe stroke in abdominally obese patients.
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Delva et al. (2013) conducted an observational in Acute ischemic non-lacunar hemispheric stroke (n=45). Abdominal obesity class II vs. Normal body weight and healthy controls was evaluated on Serum concentrations of adiponectin, leptin, and insulin resistance (HOMA-IR) index (p=<0.05). Patients with abdominal obesity class II and acute ischemic non-lacunar stroke had a significant sustained reduction in adiponectin, transient elevation in leptin, and increased insulin resistance that directly associated with cerebral infarction volumes.
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