Key result
Hypertensive patients with severe obesity had significantly higher serum leptin levels (9.74 vs 4.53 ng/ml, p<0.02) and insulin resistance (HOMA-IR 3.30 vs 1.65, p<0.02) compared to normotensive patients with simple obesity.
Population
38 out-clinic obese patients of both sexes, aged 51.9 ±13.9 years. Divided into: non-diabetic hypertensive…
Design
Cross-sectional
Authors
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Hypertension in severe obesity associates with higher leptin and insulin resistance; hypothesis-generating and requires prospective studies before clinical consideration.
Cross-Sectional (n=38)
No
Absolute Event Rate: 9.74% vs 4.53%
p-value: p=<0.02
Insulin resistance and leptin may be important pathogenic factors in hypertensive patients with severe obesity, and indices of abdominal obesity correlate better with these markers than BMI.
Stȩpień et al. (2012) conducted a cross-sectional in Obesity and Hypertension (n=38). Severe obesity with hypertension (Class II/III) vs. Simple obesity without hypertension (Class I) was evaluated on Serum leptin concentration (ng/ml) (p=<0.02). Hypertensive patients with severe obesity had significantly higher serum leptin levels (9.74 vs 4.53 ng/ml, p<0.02) and insulin resistance (HOMA-IR 3.30 vs 1.65, p<0.02) compared to normotensive patients with simple obesity.
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