Key result
Cardiopulmonary bypass activated both plasma and tissue kallikrein-kinin systems, evidenced by a 10- to 20-fold increase in bradykinin levels during the first 10 minutes.
Why the study?
Does cardiopulmonary bypass activate the plasma and tissue kallikrein-kinin systems in subjects undergoing cardiac surgery?
Population
Subjects undergoing cardiac surgery
Comparison
Cardiopulmonary bypass (CPB) vs Baseline (measurements taken before CPB)
Design
Cohort
Follow-up
10 hours after CPB
Authors
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Bradykinin surge during bypass may drive vasoactive effects; leaves open its role in clinical outcomes and targeted interventions.
Observational
Does cardiopulmonary bypass activate the plasma and tissue kallikrein-kinin systems in subjects undergoing cardiac surgery?
Cardiopulmonary bypass activates both the plasma and tissue kallikrein-kinin systems, a process that can be prevented by aprotinin administration.
Campbell et al. (2001) conducted an observational in Cardiac surgery. Cardiopulmonary bypass vs. Baseline (before cardiopulmonary bypass) was evaluated on Circulating levels of bradykinin, kallidin, plasma and tissue kallikrein, kininogen, and kallistatin. Cardiopulmonary bypass activated both plasma and tissue kallikrein-kinin systems, evidenced by a 10- to 20-fold increase in bradykinin levels during the first 10 minutes.
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