Key result
In NAFLD and obesity, Th22 and Treg cells appear to have an overall tempering effect, whereas Th17 and Tc cells seem to induce more liver damage and fibrosis progression.
Why the study?
Treatment for non-alcoholic steatohepatitis remains an unmet medical need, and the immune system, particularly diverse T-cell subsets, is a main driver of NAFLD progression and obesity-related comorbidities.
Different T-cell subsets play distinct and opposing roles in the pathogenesis of NAFLD, obesity, and insulin resistance, highlighting potential specific immune targets for metabolic diseases.
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Suggests immune targets in NAFLD merit exploration; leaves open clinical translation pending prospective validation.
Herck et al. (2019) conducted a review in Non-alcoholic fatty liver disease (NAFLD) and obesity. T cell subsets was evaluated. In NAFLD and obesity, Th22 and Treg cells appear to have an overall tempering effect, whereas Th17 and Tc cells seem to induce more liver damage and fibrosis progression.
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