Randomized trial identifies the link between disability progression and cardiovascular risks in ischemic stroke patients, suggesting the need for targeted interventions.
Key Points
This study aims to describe one-year disability trajectories and assess their associations with long-term cardiovascular events, recurrent stroke, and mortality following ischemic stroke.
Analyzed data from 3533 patients with ischemic stroke from the CATIS trial.
Identified disability trajectories using the group-based trajectory model based on the modified Rankin Scale score within 12 months.
Utilized Cox proportional hazards regression models to evaluate associations of disability trajectories with 24-month clinical outcomes.
Patients with persistent severe disability had hazard ratios of 2.63 for cardiovascular events (95% CI 1.20-5.76) and 6.10 for all-cause mortality (95% CI 2.22-16.72).
Those with severe to moderate disability had hazard ratios of 1.99 for cardiovascular events (95% CI 1.01-3.94) and 1.85 for the composite outcome of cardiovascular events and mortality (95% CI 1.03-3.33).