HIV-1 infection significantly increased the expression of HERV-K RNA and protein in vitro and in PBMCs from HIV-1 patients compared to uninfected controls.
Does HIV-1 infection increase the expression of HERV-K RNA and protein in vitro and in patient cells?
HIV-1 infection increases the expression of HERV-K RNA and protein, suggesting a potential role in HIV-1 pathogenesis and AIDS-associated cancers.
Antibodies to HERV-K antigens have been linked to HIV-1 infection and expression of HERV-K proteins generates T-cell cytotoxic responses in many cancers. HERV-K RNA and protein abundance was measured in HIV-1-infected and control cells. In vitro exposure of HIV-1 laboratory-adapted and primary isolates on U87MG cells increased the expression of HERV-K RNA in a dose-dependent manner. HERV-K RNA and protein burdens were significantly increased in HIV-1-producing H9 cell lines compared to H9 cells. The expression of HERV-K was synergistically increased in HIV-1-infected PBMCs after stimulation with PMA/ionomycin. Furthermore, the expression of HERV-K in PBMCs, and particularly in CD4(+) T cells, was higher in HIV-1 patients compared to control subjects. The expression of HERV-K might be related to HIV-1 pathogenesis and AIDS-associated cancers.
Contreras-Galindo et al. (Mon,) conducted a other in HIV-1 infection. HIV-1 infection vs. Uninfected control cells and subjects was evaluated on HERV-K RNA and protein abundance. HIV-1 infection significantly increased the expression of HERV-K RNA and protein in vitro and in PBMCs from HIV-1 patients compared to uninfected controls.