Key result
HIV-1 infection is associated with significantly increased titers of antibodies against the HERV-K (HML-2) transmembrane envelope protein compared to uninfected controls (mean titer 1:1350 vs 1:450, p < 0.0001).
Population
HIV-1 infected subjects at different stages of disease and uninfected adults
Design
Cross-sectional
Authors
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HIV-1 linked to higher anti-HERV-K titers should not change practice; hypothesis-generating for therapeutic targeting in elite controllers.
Cross-Sectional (n=200)
No
Absolute Event Rate: 1350% vs 450%
p-value: p=<0.0001
HIV-1 infection induces fully glycosylated HERV-K (HML-2) envelope TM protein, leading to specific antibody responses that are highest in elite controllers and may serve as a therapeutic target.
Michaud et al. (2014) conducted a cross-sectional in HIV-1 infection (n=200). HIV-1 infection vs. HIV-1 uninfected controls was evaluated on Anti-HERV-K (HML-2) TM antibody titer (p=<0.0001). HIV-1 infection is associated with significantly increased titers of antibodies against the HERV-K (HML-2) transmembrane envelope protein compared to uninfected controls (mean titer 1:1350 vs 1:450, p < 0.0001).
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