Key result
Exposure of the aortic surface of porcine aortic valve leaflets to pulsatile shear stress increased the expression of inflammatory markers in a TGF-beta1- and BMP-4-dependent manner.
Altered hemodynamics stimulates the expression of aortic valve leaflet endothelial adhesion molecules in a TGF-beta1- and BMP-4-dependent manner, suggesting potential targets for drug-based therapies for aortic valve diseases.
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Shear-driven AV inflammation via BMP/TGF-β1; leaves open human disease relevance and therapeutic targeting.
Sucosky et al. (2008) studied Aortic valve inflammation. Unidirectional pulsatile shear stress vs. Bidirectional oscillatory shear stress was evaluated on Expression of inflammatory markers (VCAM-1, ICAM-1, BMP-4, and TGF-beta1). Exposure of the aortic surface of porcine aortic valve leaflets to pulsatile shear stress increased the expression of inflammatory markers in a TGF-beta1- and BMP-4-dependent manner.
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