What question did this study set out to answer?

The study aims to efficiently incorporate oxetan-3-yl and azetidin-3-yl into aromatic systems.

July 9, 2008Organic Letters

Preparation of Aryloxetanes and Arylazetidines by Use of an Alkyl−Aryl Suzuki Coupling

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The study aims to efficiently incorporate oxetan-3-yl and azetidin-3-yl into aromatic systems.
Utilized nickel-mediated alkyl-aryl Suzuki coupling for synthesis.
Focused on integrating privileged motifs into aromatic compounds.
Successfully prepared aryloxetanes and arylazetidines through the proposed method.

Implication

This research presents a method to install oxetan-3-yl and azetidin-3-yl substituents using Suzuki coupling, implying utility in medicinal chemistry.

Abstract

The oxetan-3-yl and azetidin-3-yl substituents have previously been identified as privileged motifs within medicinal chemistry. An efficient approach to installing these two modules into aromatic systems, using a nickel-mediated alkyl-aryl Suzuki coupling, is presented.

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Cite This Study

Duncton et al. (2008) studied this question.

synapsesocial.com/papers/6a6a6f7eff619b1ab2cb1fc8 https://doi.org/10.1021/ol8011327

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Implication

This research presents a method to install oxetan-3-yl and azetidin-3-yl substituents using Suzuki coupling, implying utility in medicinal chemistry.

Preparation of Aryloxetanes and Arylazetidines by Use of an Alkyl−Aryl Suzuki Coupling

Key Points

Implication

Abstract

Discussion

Cite This Study

Preparation of Aryloxetanes and Arylazetidines by Use of an Alkyl−Aryl Suzuki Coupling

Key Points

Implication

Abstract

Discussion

Cite This Study

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