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July 28, 2026Journal of Functional Morphology and KinesiologyOpen Access

Acute Effects of Low-Load Blood Flow Restriction Exercise on Vastus Lateralis Electromyographic Activity in Healthy Young Adults: A Pilot Randomized Study

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Key result

Low-load exercise with blood flow restriction increases vastus lateralis sEMG amplitude ~21% versus unrestricted exercise.

  • MD 21.12%MVIC
  • 95% CI 14.54-27.71
  • P<0.001
  • n=20

Why the study?

Low-load resistance exercise with blood flow restriction may increase neuromuscular stimulation while reducing external load.

Does low-load resistance exercise with blood flow restriction increase vastus lateralis electromyographic activity compared to unrestricted exercise in healthy young adults?

Population

20 healthy young adults

Comparison

Unilateral knee extension at 20% 1RM with BFR vs without BFR

Design

Pilot randomized study

Authors

RGRafael Gómez GarcíaMCMaría de los Ángeles Cardero‐DuránLELuís Espejo-Antúnez

Discussion

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Overview

Supports BFR with low-load exercise to enhance quadriceps activation in training; extends acute neuromuscular evidence from prior studies.

Study Design

Type

RCT (n=20)

Randomization

Randomized

Structured PICO

Does low-load resistance exercise with blood flow restriction increase vastus lateralis electromyographic activity compared to unrestricted exercise in healthy young adults?

P
Population
20 healthy young adults who completed a single session of unilateral knee extension with and without blood flow restriction.
I
Intervention
Unilateral knee extension at 20% one-repetition maximum (1RM) with blood flow restriction (BFR) at 80% estimated arterial occlusion pressure (AOP) (75 repetitions: 30-15-15-15)
C
Comparator
Same unilateral knee extension protocol without BFR on the contralateral limb
O
Outcome
Normalized RMS amplitude across 12 protocol windowssurrogate

Main Result

Mean Difference: 21.12 (95% CI 14.54–27.71)

p-value: p=<0.001

Low-load resistance exercise with blood flow restriction acutely increases vastus lateralis electromyographic amplitude compared to unrestricted exercise in healthy young adults.

Limitations

  • MVIC-derived findings were exploratory and should not be interpreted as evidence of preserved strength or reduced neuromuscular fatigue
  • Small sample size
  • Lack of clinical populations
  • Requires larger studies including clinical populations

Cite This Study

García et al. (2026) conducted an RCT in Healthy young adults (n=20). Low-load resistance exercise with blood flow restriction (BFR) vs. Same protocol without BFR was evaluated on Normalized RMS amplitude across 12 protocol windows (MD 21.12%MVIC, 95% CI 14.54-27.71, p=<0.001). Low-load resistance exercise with blood flow restriction increased vastus lateralis sEMG amplitude compared to unrestricted exercise (mean difference 21.12%MVIC; 95% CI 14.54-27.71; p<0.001).

synapsesocial.com/papers/6a6a6f8345e10bb5bcf2b87fhttps://doi.org/10.3390/jfmk11030298
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Myoelectric Activity and Fatigue in Low-Load Resistance Exercise With Different Pressure of Blood Flow Restriction: A Systematic Review and Meta-Analysis2021 · 30 citations
  2. 2Acute Effects of Blood Flow Restriction on Muscle Activity and Endurance During Fatiguing Dynamic Knee Extensions at Low Load2009 · 189 citations
  3. 3Immediate Effects of Blood Flow Restriction Combined with Neuromuscular Electrical Stimulation in Female Amateur Football Players: A Pilot Trial2023 · 3 citations
  4. 4The Discrepancy Between External and Internal Load/Intensity during Blood Flow Restriction Exercise: Understanding Blood Flow Restriction Pressure as Modulating Factor2024 · 11 citations
  5. 5Blood Flow Restriction Exercise: Considerations of Methodology, Application, and Safety2019 · 903 citations