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This research aims to characterize the 2022 Sudan virus outbreak in Uganda and assess the genetic relationships of the virus strains.

September 26, 2023Journal of VirologyOpen Access

Molecular characterization of the 2022 Sudan virus disease outbreak in Uganda

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Randomized trial evaluates genetic relatedness and spread of Sudan virus in Uganda, suggesting enhanced outbreak response strategies.

This research aims to characterize the 2022 Sudan virus outbreak in Uganda and assess the genetic relationships of the virus strains.
Performed unbiased Illumina and SUDV-amplicon-specific Minion sequencing on 142 confirmed cases.
Analyzed nucleotide genetic relatedness among newly emerged Mubende variant and historical strains.
Integrated genetic sequence data with epidemiological data for outbreak response.
120 complete SUDV genomes were sequenced, representing 95.4% of confirmed cases.
The Mubende variant showed 96% amino acid similarity to historical strains and 99.7% similarity among itself.
Identified inter- and intra-outbreak genetic differences were linked to patient contact tracing.

Balinandi et al. (2023) studied this question.

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