Key result
In obese children and adolescents, the presence of NAFLD was significantly associated with higher levels of total cholesterol, LDL-C, triglycerides, and insulin resistance (p<0.05).
Why the study?
To determine the relationship between lipid profile and non-alcoholic fatty liver disease in obese children and adolescents.
Does lipid profile correlate with the presence of non-alcoholic fatty liver disease in obese children and adolescents?
Population
290 children and adolescents diagnosed with obesity
Comparison
Children and adolescents diagnosed with NAFLD by USG vs those without NAFLD
Design
Comparative cross-sectional study
Authors
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May support lipid and IR monitoring in obese youth with NAFLD; leaves open causal direction and prospective validation.
Cross-Sectional (n=290)
No
Does lipid profile correlate with the presence of non-alcoholic fatty liver disease in obese children and adolescents?
p-value: p=<0.05
In obese children and adolescents, elevated total cholesterol, LDL-C, and triglycerides are significantly correlated with the presence of NAFLD, and specific ALT thresholds can serve as diagnostic biomarkers.
Çığrı et al. (2022) conducted a cross-sectional in Obesity and non-alcoholic fatty liver disease (n=290). Non-alcoholic fatty liver disease (NAFLD) vs. Without NAFLD was evaluated on Clinical and biochemical findings including lipid profile and insulin resistance markers (p=<0.05). In obese children and adolescents, the presence of NAFLD was significantly associated with higher levels of total cholesterol, LDL-C, triglycerides, and insulin resistance (p<0.05).
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