What question did this study set out to answer?

This research investigates how interleukin-23 influences T cell behavior to drive intestinal inflammation.

Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells

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Randomized trial demonstrates IL-23's role in T cell activity for intestinal inflammation, suggesting new treatment avenues.

This research investigates how interleukin-23 influences T cell behavior to drive intestinal inflammation.
Used Il23r(-/-) T cells to examine effects of IL-23 on T cell reactivity and intestinal pathology.
Assessed T cell proliferation and differentiation in response to IL-23 signaling.
Analyzed various T cell populations including Th17 and Foxp3(+) cells.
IL-23 promoted intestinal T cell proliferation and increased Th17 cell accumulation.
Il23r(-/-) T cells showed impaired proliferation but normal Th1 differentiation.
IL-23R signaling suppressed Foxp3(+) cell differentiation and T cell IL-10 production.

Ahern et al. (2010) studied this question.

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