Key result
Newer generation tyrosine kinase inhibitors, particularly nilotinib and ponatinib, are associated with an increased risk of vascular adverse events in patients with chronic myeloid leukemia.
Why the study?
What is the clinical spectrum, pathogenesis, and management of TKI-associated vascular adverse events in patients with CML?
What is the clinical spectrum, pathogenesis, and management of TKI-associated vascular adverse events in patients with CML?
This review highlights the emerging issue of vascular adverse events associated with newer TKIs in CML and discusses strategies for prevention, monitoring, and management.
TKI-associated VAEs in CML warrant clinical vigilance; review leaves open comparative risk data for agent selection.
Tyrosine kinase inhibitors (TKIs) have revolutionized the management and outcomes of chronic myeloid leukemia (CML) patients. Improved disease control and prolonged life expectancy now mandate focus on improving TKIs' safety profile. Recently, vascular adverse events (VAEs) have emerged as a serious consequence of some of the newer TKIs. In this review, we describe the clinical spectrum of TKI-associated VAE, and examine the unique vascular safety profile of the main TKIs currently used in the treatment of CML: imatinib, nilotinib, dasatinib, bosutinib and ponatinib. The issue of TKI-related platelet dysfunction is discussed as well. We describe the contemporary research findings regarding the possible pathogenesis of the VAE. Finally, the different aspects of TKI-associated VAE management are addressed, including prevention methods, monitoring strategies and treatment options.
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Pasvolsky et al. (2015) conducted a review in Chronic myeloid leukemia (CML). Tyrosine kinase inhibitors (TKIs) was evaluated. Newer generation tyrosine kinase inhibitors, particularly nilotinib and ponatinib, are associated with an increased risk of vascular adverse events in patients with chronic myeloid leukemia.
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