Key result
Venlafaxine and O-desmethylvenlafaxine clearance was significantly decreased by approximately 55% in subjects receiving dialysis, warranting dosage adjustment in severe renal disease.
Why the study?
Does renal dysfunction alter the pharmacokinetics and disposition of a single dose of venlafaxine?
Population
Subjects with various degrees of renal dysfunction, including subjects requiring maintenance hemodialysis.
Design
Other
Follow-up
Up to 48 hours for subjects receiving dialysis, or 72…
Authors
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Supports venlafaxine dose adjustment in severe renal impairment; leaves open prospective outcome validation.
Does renal dysfunction alter the pharmacokinetics and disposition of a single dose of venlafaxine?
Effect estimate: decreased by approximately 55%
The disposition of venlafaxine is markedly altered in renal disease, warranting dosage adjustment for patients with creatinine clearance below 30 ml/min.
Troy et al. (1994) studied Renal dysfunction. Venlafaxine vs. Subjects with varying degrees of renal dysfunction / not receiving dialysis was evaluated on Apparent total clearance and terminal disposition half-life of venlafaxine and O-desmethylvenlafaxine (decreased by approximately 55%). Venlafaxine and O-desmethylvenlafaxine clearance was significantly decreased by approximately 55% in subjects receiving dialysis, warranting dosage adjustment in severe renal disease.
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