Key result
Different cardiac regions express different HCN isoforms, with HCN1 and HCN4 associated with a depolarized threshold for If activation and HCN2 associated with a more negative activation curve.
Different cardiac regions express distinct HCN isoforms, which correlates with the voltage dependence of the hyperpolarization-activated current (If).
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Differential HCN isoform expression in animal pacemaker tissue extends If current heterogeneity data; leaves open human SA node translation.
Shi et al. (1999) studied this question. HCN isoform expression analysis was evaluated on HCN cation channel mRNA expression and isoform prevalence in cardiac tissues. Different cardiac regions express different HCN isoforms, with HCN1 and HCN4 associated with a depolarized threshold for If activation and HCN2 associated with a more negative activation curve.
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