Key result
The HCN gene family encodes the hyperpolarization-activated cation channels underlying the anomalous rectifying current (Ih, Iq, or If) in cardiovascular physiology and neurobiology.
Design
Review
Authors
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May inform HCN-targeted therapies; leaves open prospective clinical validation in arrhythmias.
This review provides foundational knowledge on the molecular basis of the HCN gene family and its role in encoding the hyperpolarization-activated pacemaker current.
Santoro et al. (1999) reported a review. HCN gene family was evaluated. The HCN gene family encodes the hyperpolarization-activated cation channels underlying the anomalous rectifying current (Ih, Iq, or If) in cardiovascular physiology and neurobiology.
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