Key result
The HCN gene family encodes the hyperpolarization-activated cation channels underlying the anomalous rectifying current (Ih, Iq, or If) in cardiovascular physiology and neurobiology.
This review provides foundational knowledge on the molecular basis of the HCN gene family and its role in encoding the hyperpolarization-activated pacemaker current.
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May inform HCN-targeted therapies; leaves open prospective clinical validation in arrhythmias.
Santoro et al. (1999) reported a review. HCN gene family was evaluated. The HCN gene family encodes the hyperpolarization-activated cation channels underlying the anomalous rectifying current (Ih, Iq, or If) in cardiovascular physiology and neurobiology.
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