Population
Xenopus oocytes expressing HCN1 and HCN2 isoforms
Comparison
Coexpression of HCN1 and HCN2 vs Independent populations of HCN1 and HCN2 homomers
Design
Preclinical
Authors
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Caution against applying heteromeric Ih kinetics to human pacemaking; extends neuronal channel data but leaves cardiac validation open.
HCN1 and HCN2 coassemble to form heteromeric channels with novel biophysical properties that closely resemble native Ih in hippocampal neurons.
Chen et al. (2001) studied this question.
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