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March 15, 2001European Journal of Biochemistry

Cellular expression and functional characterization of four hyperpolarization‐activated pacemaker channels in cardiac and neuronal tissues

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Population

Murine sinoatrial node, retina, and dorsal root ganglion tissues, and recombinant HCN1-4 channels expressed…

Design

Preclinical

Authors

SMSven MoosmangBoehringer Ingelheim (Germany)JSJuliane StieberApple (Israel)XZXiangang ZongCenter for Integrated Protein Science Munich

Discussion

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Overview

May explain I(h) heterogeneity across tissues; hypothesis-generating for isoform-selective HCN modulation in arrhythmia or sensory disorders.

Structured PICO

P
Population
Murine sinoatrial node, retina, and dorsal root ganglion (DRG) tissues, and recombinant HCN1-4 channels expressed in HEK293 cells
I
Intervention
In situ hybridization for transcript distribution and functional characterization of recombinant channels
O
Outcome
Cellular distribution of HCN1-4 transcripts and functional properties (activation kinetics) of recombinant channelssurrogate

The heterogeneity of native hyperpolarization-activated cation currents is partly generated by tissue-specific expression of HCN channel genes.

Cite This Study

Moosmang et al. (2001) studied this question.

synapsesocial.com/papers/6a6feef5f44fa9f079dd6e4dhttps://doi.org/10.1046/j.1432-1327.2001.02036.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1H-Current1998 · 427 citations
  2. 2Characterization of a hyperpolarization‐activated current in dedifferentiated adult rat ventricular cells in primary culture1998 · 37 citations
  3. 3Pacemaker current i(f) in adult canine cardiac ventricular myocytes.1995 · 116 citations
  4. 4Occurrence and Properties of the Hyperpolarization-Activated Current I f in Ventricular Myocytes From Normotensive and Hypertensive Rats During Aging1996 · 165 citations
  5. 5Conduction velocity is related to morphological cell type in rat dorsal root ganglion neurones.1985 · 755 citations