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July 3, 2009Journal of Biological ChemistryOpen Access

Proteolytic Processing of HCN2 and Co-assembly with HCN4 in the Generation of Cardiac Pacemaker Channels

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Authors

BYBin YeSun Yat-sen University JNJeanne M. NerbonneElectrophysiology

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Implication

Supports heteromeric HCN2-HCN4 channel formation in nodal tissue; leaves open relative roles in native I(f) and arrhythmia targets.

Key Points

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Cite This Study

Ye et al. (2009) studied this question.

synapsesocial.com/papers/6a6fa28df44fa9f079dd1a01 https://doi.org/10.1074/jbc.m109.007583

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Occurrence and Properties of the Hyperpolarization-Activated Current I f in Ventricular Myocytes From Normotensive and Hypertensive Rats During Aging1996 · 165 citations
2HCN2 and HCN4 Isoforms Self-assemble and Co-assemble with Equal Preference to Form Functional Pacemaker Channels2007 · 55 citations
3Dominant-Negative Suppression of HCN Channels Markedly Reduces the Native Pacemaker Current I f and Undermines Spontaneous Beating of Neonatal Cardiomyocytes2003 · 99 citations
4Properties of Hyperpolarization-Activated Pacemaker Current Defined by Coassembly of Hcn1 and Hcn2 Subunits and Basal Modulation by Cyclic Nucleotide2001 · 418 citations
5A Conserved Domain in the NH2 Terminus Important for Assembly and Functional Expression of Pacemaker Channels2002 · 38 citations