What is the clinical evidence from this study?

Study design: Other. Intervention: HCN2 and HCN4 co-assembly. Primary outcome: Co-assembly of HCN2 and HCN4.

June 7, 2007Journal of Biological ChemistryOpen Access

HCN2 and HCN4 Isoforms Self-assemble and Co-assemble with Equal Preference to Form Functional Pacemaker Channels

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Key result

HCN2 and HCN4 subunits self-assemble and co-assemble with equal preference to form functional heteromeric channels in live cells and native tissues.

Authors

GWGina M. WhitakerUniversity of British Columbia DADamiano AngoliUniversity of Florida HNHamed NazzariUniversity of British Columbia

Discussion

Member takes

Implication

Hypothesis-generating for HCN heteromer roles in cardiac pacemaking; leaves open functional validation in disease models.

PICO

Exposure / Comparator

HCN2 and HCN4 co-assembly

Primary Outcome

Co-assembly of HCN2 and HCN4

Cite This Study

Whitaker et al. (2007) studied this question. HCN2 and HCN4 co-assembly was evaluated on Co-assembly of HCN2 and HCN4. HCN2 and HCN4 subunits self-assemble and co-assemble with equal preference to form functional heteromeric channels in live cells and native tissues.

synapsesocial.com/papers/6a9185a29ea92d4f71f08c32 https://doi.org/10.1074/jbc.m610978200

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HCN2 and HCN4 Isoforms Self-assemble and Co-assemble with Equal Preference to Form Functional Pacemaker Channels

Discussion

Member takes

Implication

PICO

Cite This Study

HCN2 and HCN4 Isoforms Self-assemble and Co-assemble with Equal Preference to Form Functional Pacemaker Channels

Discussion

Member takes

Implication

PICO

Cite This Study

Also Consider

Also Consider