Population
Chinese hamster ovary cells and yeast two-hybrid system models
Design
Preclinical
Authors
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No immediate clinical implications for arrhythmia therapy; extends molecular models of HCN heteromerization while leaving in vivo function open.
The N-terminus is essential for HCN channel assembly, while the cyclic nucleotide binding domain is required for functional expression of homomeric but not necessarily all subunits of heteromeric channels.
Proenza et al. (2002) studied this question.
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