Why the study?
Although coupling between voltage- and cNMP-dependent activation in HCN channels was suggested, the specific functional significance of the newly identified HCN domain remained unclear.
Population
HCN2 channels
Comparison
HCND deletion and residue disruption vs intact channels
Design
Preclinical functional and structural analysis study
Authors
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HCND is critical for HCN channel expression and gating; leaves open its potential as a therapeutic target in cardiac arrhythmias.
The HCN domain is essential for the surface expression of HCN channels and functionally couples their voltage- and cAMP-dependent gating mechanisms.
Wang et al. (2020) studied this question.
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