Key result
Analysis of native human atrial If revealed half-maximal activation at -68.3+/-4.9 mV, which falls within the diastolic voltage range and supports a potential contribution to arrhythmogenesis.
Population
Heterologously expressed hyperpolarization-activated cyclic nucleotide-gated isoforms and native human…
Design
Preclinical
Authors
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First single-channel HCN data may clarify I(f) diastolic activation; leaves open any arrhythmogenic role in diseased myocardium.
Single-channel analysis reveals that the activation threshold of native I(f) channels in human atrial myocardium is within the diastolic voltage range, suggesting a potential mechanism for arrhythmogenesis under pathological conditions.
Michels et al. (2005) studied Cardiac Arrhythmias. Heterologously expressed HCN isoforms and native human If was evaluated on Single-channel properties including amplitude, conductance, and activation kinetics. Analysis of native human atrial If revealed half-maximal activation at -68.3+/-4.9 mV, which falls within the diastolic voltage range and supports a potential contribution to arrhythmogenesis.
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