Non-equilibrium behavior of HCN channels: Insights into the role of HCN channels in native and engineered pacemakers
Population
Xenopus laevis oocytes or mammalian Cos7 cells heterologously expressing HCN1, 2 and 4 channels
Design
Preclinical
Authors
Discussion
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Member takes
Implication
HCN1 hysteresis may shape pacemaker activity; extends isoform biophysics but leaves human translation open.
Structured PICO
P
Population
Xenopus laevis oocytes or mammalian Cos7 cells heterologously expressing HCN1, 2 and 4 channels
I
Intervention
Voltage clamp experiments and computational modeling
O
Outcome
HCN channel activation (V1/2) and current-voltage (IV)-hysteresissurrogate
Non-equilibrium properties of HCN channels, particularly the IV-hysteresis of HCN1, contribute to cardiac pacing and provide insights for tuning endogenous and induced pacemakers.
Cite This Study
Azene et al. (2005) studied this question.