Key result
The pattern of splicing and different promoter usage of the PDE4D gene is conserved during evolution, with PDE4D1, PDE4D2, and PDE4D3 variants expressed in human peripheral blood mononuclear cells.
Authors
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No immediate clinical implications from PDE4D conservation; leaves open functional roles in human cardiovascular inflammation.
Némoz et al. (1996) studied this question. PDE4D gene expression analysis was evaluated on Expression and characterization of PDE4D variants. The pattern of splicing and different promoter usage of the PDE4D gene is conserved during evolution, with PDE4D1, PDE4D2, and PDE4D3 variants expressed in human peripheral blood mononuclear cells.
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