Key result
The homozygous C allele at position -18 (CC/C-18T) in the AGT gene was significantly associated with an increased risk of essential hypertension (OR 4.2; 95% CI 1.4-12.8; P<.005).
Why the study?
Are variants in the core promoter element 1 of the angiotensinogen gene associated with an increased risk of essential hypertension in Japanese subjects?
Population
374 Japanese subjects, comprising 180 patients with documented essential hypertension and a family history…
Comparison
Presence of genetic variants in the core… vs Absence of these genetic variants.
Design
Case-control
Authors
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AGT promoter variants may associate with familial hypertension risk; leaves open causal validation and clinical utility.
Case-Control (n=374)
Are variants in the core promoter element 1 of the angiotensinogen gene associated with an increased risk of essential hypertension in Japanese subjects?
Odds Ratio: 4.2 (95% CI 1.4–12.8)
p-value: p=<.005
The C-18T polymorphism in the AGCE1 promoter of the angiotensinogen gene is a significant genetic risk factor for essential hypertension in the Japanese population.
Sato et al. (1997) conducted a case-control in Essential hypertension (n=374). Homozygous C allele at position -18 (CC/C-18T) in AGCE1 vs. CT/C-18T genotype was evaluated on Essential hypertension (OR 4.2, 95% CI 1.4 to 12.8, p=<.005). The homozygous C allele at position -18 (CC/C-18T) in the AGT gene was significantly associated with an increased risk of essential hypertension (OR 4.2; 95% CI 1.4-12.8; P<.005).
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