Key result
Microinjection of Angiotensin II into vascular smooth muscle cells led to a rapid increase in cytosolic and nuclear Ca2+, which subsequently stimulated adjacent cells via cell-cell contact.
Population
Vascular smooth muscle cells (VSMCs)
Comparison
Microinjection of Angiotensin II (10(-10) mol/L) vs Concomitant injection of Ang II antagonist…
Design
Preclinical
Authors
Loading...
May modulate VSMC Ca2+ signaling; leaves open its role in vascular disease.
Intracellular Angiotensin II binds to intracellular receptors to increase cytosolic calcium in the injected cell and adjacent cells via cell-cell contact, suggesting a mechanism for stimulating clusters of VSMCs.
Haller et al. (1996) studied this question. Intracellular Angiotensin II was evaluated on Cytosolic Ca2+ ([Ca2+]i) increase. Microinjection of Angiotensin II into vascular smooth muscle cells led to a rapid increase in cytosolic and nuclear Ca2+, which subsequently stimulated adjacent cells via cell-cell contact.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: