Population
Cultured rat aortic vascular smooth muscle cells (VSMC)
Comparison
Angiotensin II and ANG II-colloidal gold complex vs Control probe (no ANG II) and losartan potassium
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether ANG II internalization modulates vascular responses in humans.
This study demonstrates the specific, receptor-mediated internalization pathway of angiotensin II in vascular smooth muscle cells via coated pits into lysosome-like vesicles.
Anderson et al. (1993) studied this question.
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