Key result
Fluorescently labeled Ang II and AT1a receptors were rapidly internalized into endosomes and recycled, whereas AT2 receptors remained in the plasma membrane and did not undergo endocytosis.
Population
Human embryonal kidney 293 cells stably expressing AT1a and AT2 receptor subtypes
Design
Preclinical
Authors
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Does not support changes in RAAS targeting; leaves open subtype-specific trafficking as a therapeutic hypothesis.
The study demonstrates subtype-specific receptor sorting, showing that AT1a receptors internalize and recycle upon Ang II stimulation, while AT2 receptors do not undergo endocytosis.
Hein et al. (1997) studied this question. Angiotensin II was evaluated on Cellular trafficking pathways of Ang II and its AT1a and AT2 receptors. Fluorescently labeled Ang II and AT1a receptors were rapidly internalized into endosomes and recycled, whereas AT2 receptors remained in the plasma membrane and did not undergo endocytosis.
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