Population
Preclinical model (rat AT1A and AT2 receptors)
Design
Preclinical
Authors
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Hypothesis-generating for AT1/AT2-selective ligands; should not yet alter clinical angiotensin receptor targeting.
Demonstrates that AT1 and AT2 angiotensin receptors have distinct regulatory mechanisms regarding beta-arrestin binding and internalization.
Turu et al. (2005) studied this question.
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