What does this research mean for the field?

Circulating Angiotensin II, but not Angiotensin I, accumulates in tissues such as the heart, kidney, and adrenal glands via AT1 receptor-mediated internalization, resulting in a significantly prolonged intracellular half-life compared to its circulating half-life. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

July 1, 1997Hypertension

Angiotensin II Type 1 (AT1) Receptor–Mediated Accumulation of Angiotensin II in Tissues and Its Intracellular Half-life In Vivo

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Population

Pigs (n=6 experiments)

Design

Preclinical

Authors

JKJorge P. van KatsErasmus MC LLLarissa M. de LannoyLeiden University ADA.H. Jan DanserVascular Medicine

Discussion

Member takes

Implication

Supports AT1-mediated Ang II accumulation in animal tissues; hypothesis-generating for intracellular Ang II effects in human disease.

Structured PICO

Population

Pigs (n=6 experiments)

Intervention

Infusion of 125I-Ang II and 125I-Ang I into the left cardiac ventricle, with or without a specific AT1 receptor antagonist

Outcome

Levels and steady-state concentrations of 125I-Ang II and 125I-Ang I in tissues (skeletal muscle, heart, kidney, adrenal) and blood plasma, and in vivo half-lifesurrogate

Angiotensin II is accumulated in tissues such as the heart, kidney, and adrenal gland via AT1 receptor-mediated internalization, protecting it from rapid degradation and extending its half-life.

Cite This Study

Kats et al. (1997) studied this question.

synapsesocial.com/papers/6a1eb53e94615786b59a73bf https://doi.org/10.1161/01.hyp.30.1.42

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Angiotensin II Type 1 (AT1) Receptor–Mediated Accumulation of Angiotensin II in Tissues and Its Intracellular Half-life In Vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II Type 1 (AT1) Receptor–Mediated Accumulation of Angiotensin II in Tissues and Its Intracellular Half-life In Vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider