Population
9 pigs (5 control, 4 pretreated with AT1 receptor antagonist eprosartan)
Comparison
1 h infusion of 125I-angiotensin I or… vs Control pigs (no eprosartan)
Design
Preclinical
Follow-up
1 hour
Authors
Loading...
May support extracellular angiotensin II synthesis in adrenal and kidney; leaves open human relevance and requires further study.
Local angiotensin II synthesis in adrenal and kidney occurs predominantly extracellularly, followed by rapid AT1 receptor-mediated endocytosis.
Kats et al. (2001) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: