Population
Male Sprague-Dawley rats
Comparison
High or low dietary sodium for 10-14 days; acute… vs High vs low dietary sodium; enalaprilat vs no…
Design
Preclinical
Follow-up
10-14 days
Authors
Loading...
Acute ACE inhibition suppresses renal microdomain ANG II in rats; extends intrarenal RAS localization but leaves open human translation.
Intact angiotensin peptides and ACE activity are present in renal intermicrovillar clefts and endosomes, indicating intracellular formation and/or trafficking dependent on ACE activity.
Imig et al. (1999) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: