What question did this study set out to answer?

This research aims to estimate how much angiotensin I and II is produced at tissue sites compared to circulating levels.

Production of angiotensins I and II at tissue sites in intact pigs

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Population

Anesthetized pigs

Design

Preclinical

Authors

Hypothesis-generating for local RAS in vivo; leaves open human translation and therapeutic relevance.

This research aims to estimate how much angiotensin I and II is produced at tissue sites compared to circulating levels.
Measured angiotensin I and II in arterial and venous plasma across various vascular beds.
Conducted constant infusion of radiolabeled angiotensin I into the left cardiac ventricle of anesthetized pigs.
Assessed production in various tissues including lungs, myocardium, skin, and kidneys.
In lungs, 31% of venous angiotensin II was from de novo production; angiotensin I was minimal.
De novo production percentages for angiotensin I in myocardium, head, skin, skeletal muscle, and kidney were 40%, 58%, 55%, 67%, and 94%, respectively.
Some circulating angiotensin II may not originate from circulating angiotensin I, indicating alternative production pathways.

Population

Anesthetized pigs

Intervention

Constant infusion of 125I-ANG I into the left cardiac ventricle

Outcome

Levels of ANG I and II and their radiolabeled counterparts in arterial and venous plasma across various vascular bedssurrogate

Production of angiotensin I and II at tissue sites significantly contributes to their circulating levels in intact pigs.

Danser et al. (1992) studied this question.

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